Pilocarpine

Transtympanic pilocarpine in tinnitus.

In 48 patients who had neurosensory hypoacusia and whose main complaint was tinnitus, a 1% pilocarpine solution or a 2% carbachol Isopto solution was placed in the tympanic cavity by means of a No. 26 pencil-tipped lumbar puncture needle through the front quadrant of the eardrum. Patients were chosen without regard for age, gender, or topographical damage of the acoustic pathway. Evaluation of ...

The effect of pilocarpine on tumor growth.

The administration of pilocarpine has been shown to increase tissue levels of specific proteins in several biological systems, possibly by exerting an effect on protein synthesis. Litarczek has shown that the administration of pilocarpine causes an increased antibody production in rabbits given inoculations of typhus bacillus (6), and recent investigations have indicated that an in creased accu...

Effects of Pilocarpine on Ocular Tension Dynamics.

Pilocarpine has been used since 1877 in the treatment of glaucoma because of its effect in lowering intraocular pressure. How­ ever, it is only since the advent of tonography and anterior chamber perfusion tech­ niques that the mechanism of this effect has been investigated. It was the purpose of this study to evalu­ ate further the effects of pilocarpine by means of diurnal tonometric and tono...

Response to Pilocarpine in Cases of Asthma

The pilocarpine model of temporal lobe epilepsy

Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the use of models of status epilepticus (SE), as in the case of the pilocarpine model. The main features of TLE are: (i) epileptic foci in the limbic system; (ii) an "initial precipitating injury"; (iii) the so-called "latent period"; and (iv) the presence of hippocampal sclerosis leading to reorganization of ...